Understanding Tangential Flow Filtration (TFF) Systems
Tangential Flow Filtration (TFF) systems, also known as cross-flow filtration systems, are membrane-based technologies widely used in bioprocessing for the concentration, diafiltration, and purification of biomolecules such as proteins, enzymes, viruses, and cell suspensions. In TFF, the process fluid flows tangentially across the membrane surface, which minimises fouling and enables continuous, efficient separation—allowing smaller molecules to pass through as permeate while retaining larger molecules in the retentate. Available in various formats, including cassette, hollow-fibre, and ceramic designs, TFF systems are scalable from laboratory to industrial production and can feature single-use or multi-use configurations. These systems help improve product purity, reduce processing time, and ensure consistent performance in biopharmaceutical, biotechnology, and industrial applications.
