(DELTA 2-24)
Highest level of process-control and reproducibility for rapid, safe freeze drying of your high-quality products.
With 50 years of experience, Martin Christ GmbH is the leading producer of, not only routine-process freeze dryers, but also of a series of product-specific, highly specialized freeze dryers with far reaching potential. This line of equipment is distinguished by its innovative Lyo-Screen-Control (LSC) interface, its exceptional design and the most advanced level of refrigeration and vacuum technology. The freeze dryers are available as laboratory freeze dryers with cylindrical drying chambers and pilot systems with rectangular cross-section drying chambers. A practical and diverse collection of accessories permits a wide range of tasks. Outstanding products, superior technology and full customer support. Applying advanced processes to valuable products requires specific system configuration. We offer extensive advice in selecting a system and, on request, will run a freeze-drying test in our applications laboratory. Martin Christ's high-quality freeze dryers are equipped with a modern, intuitive interface known as the Lyo-Screen-Control(LSC). This interface is used throughout our line of laboratory and pilot freeze dryers. It allows for up to 30 different drying programs with even the smallest machine as well as for the connection to a PC for process documentation and process control.
The best in specific systems and process monitoring.
Freeze dryers are increasingly being used for small batches whose production involves detailed information to create validation documents (IQ/OQ documentation) and to prepare monitoring tools that ensure flawless product quality. We not only use standard measurements of product temperature and pressure, but also measurements of electrical resistance (Lyo-control) and weight-change (weighing cell) during the drying process. Optimal product safety can thus be guaranteed. Unacceptable structural changes including the collapse of the matrix, i.e. possible cross-contamination during the drying phase, can be avoided with confidence..
Laboratory Freeze Dryers
The optimal system for advanced applications:
• compact, high-performance laboratory and technical equipmentrequiring minimal space
• modular systems permit capacity expansion with a wide varietyof accessories
• complete processing of entire freeze-drying cycle in ice condenser chamber, program controlled, if desired, from-30°C (prefreezing) with single-stage compressors, to -50°C(prefreezing) with doublestage compressors
• innovative, easy-to-use interface LSC with PC connection for process control and documentation
• freeze-dryer system fulfills FDA and cGMP-Guidelines, interfacefulfills the current requirements according to GAMP, Lyo-software LPC-16 also meets US CFR requirements
• drying chamber is located directly above the ice condenser chamber; maximum cross-sectional area results in high sublimation performance and shortest possible process-time
• ice condenser chamber with inner condenser coil of high- quality steel allows for efficient vapour deposition
• thermal insulation of ice condenser chamber avoids power loss and eliminates build-up of water condensation
• ice condenser can be checked visually
• easily accessible ice condenser; rapid, easy defrosting and cleaning (electrical or hot-gas defrosting available); mechanicalor electric defrosting drain
• chemically resistant systems for freeze drying solvents (e.g. DMSO, Acetonitrile, Tert-Butanol, Dioxane) are available
• Windows-based software LPC-16 (Lyophilization Process Control)for PC process control and documentation available with all systems
• simple alternative process documentation using Martin Christprinter or Lyolog LL-1 software
• when required, system qualification (IQ/OQ documentation) for validation purposes
Pilot Freeze Dryers
The highest level of research and development for newproducts.
The Epsilon 1-4 / 2-4 and Epsilon 1-6 D / 2-6 D set the standard for pilot systems of the highest quality and performance. They share a geometrical likeness with large production machines and use similar temperature-controlling systems. The Epsilon 1-4 / 2-4 units have an ice condenser temperature with a minimum of -55°C and -85°C respectively and is available with one shelf with 0.11 m2 usable surface area. The anodized Aluminium shelves can be directly heated or cooled, making the Epsilon 1-4 / 2-4 suitable for both experimental and routine freeze drying. The two larger models, Epsilon 1-6 D and 2-6 D, are characterized by their drying potential on a maximum of four shelves with an area of 0.28 m2, their distance between shelves can reach 75mm(with three shelves). Due to the temperature control of the stainless steel shelves (via a synthetic heat-transfer medium), these pilot systems fulfil the highest standards of the pharmaceutical and biotech industries. New cooling techniques allow for shelf temperatures of -40°C and -55°C/-70°C (pre-freezing) in the very compact chambers of the Epsilon 1-4 and 1-6 D and the Epsilon 2-4 and 2-6 D, respectively. This permits extremely sensitive pharmaceutical and biotech products, e.g. amorphous structures with a low glass transition point, to be freeze dried safely. These pilot dryers are also available with liquid nitrogen cooling. Simple, process-specific documentation is possible on all systems as a result of the new Lyo-Screen-Control and Lyolog interface. The innovative weighing cell provides the ability to monitor freeze drying in vials and trays, in addition to the standard measurements of product temperature and pressure. An added option is the Windows-based LPC-16 software for PC process control and documentation. LPC-16 is widely used in large freeze-drying production systems and follows the GAMP and cGMP guidelines. Other cGMP guidelines are also followed including maintenance and surface guidelines. The systems can be H2O2 sterilized and can be delivered with an Installation/Operation qualification. All systems are very flexible; all are available with manual stoppering devices and additional manifolds for lyophilization in round bottom flasks. These systems will contribute to the success of your small batch production and product development.
Technical Information
Model |
GAMMA 1-16 |
GAMMA 2-16 |
DELTA 1-24 |
DELTA 2-24 |
Ice condenser capacity |
max. 16 kg |
max. 16 kg |
max. 24 kg |
max. 24 kg |
Ice condenser performance |
max. 12 kg/24 h |
max. 12 kg/24 h |
max. 18 kg/24 h |
max. 18 kg/24 h |
Ice condenser temperature |
approx. -60°C |
approx. -85°C |
approx. -55°C |
approx. -85°C |
Shelf temperature when pre-freezing inside the ice
condenser chamber |
approx. -40°C |
approx. -55°C |
approx. -40°C |
approx. -55°C |
Max. shelf surface area when drying inside the ice condenser chamber (process A) |
5 shelves
ø=200 mm,
^= 0.155 m2 |
5 shelves
ø=200 mm,
^= 0.155 m2 |
10 shelves
ø=200 mm,
^=0.31 m2 |
10 shelves
ø=200 mm,
^= 0.31 m2 |
Max. shelf surface area when drying inside the ice condenser chamber in injection vials with stoppering under vacuum or inertgas (process A) |
2 shelves
ø=250 mm,
^= 0.09 m2 |
2 shelves
ø=250 mm,
^= 0.09 m2 |
4 shelves
ø=250 mm,
^= 0.18 m2 |
4 shelves
ø=250 mm,
^= 0.18 m2 |
Max. shelf surface area when drying outside the ice condenser chamber (process B) |
8 shelves
ø=375 mm,
^= 0.88 m2 |
8 shelves
ø=375 mm,
^= 0.88 m2 |
8 shelves
ø= 375 mm,
^= 0.88 m2 |
8 shelves
ø= 375 mm,
^= 0.88 m2 |
Max. shelf surface area when drying outside the ice condenser chamberin injection vials with stoppering under vacuum or inert gas (process B) |
4 shelves
ø= 250 mm,
^= 0.18 m2 |
4 shelves
ø= 250 mm,
^= 0.18 m2 |
4 shelves
ø= 250 mm,
^= 0.18 m2 |
4 shelves
ø= 250 mm,
^= 0.18 m2 |
Drying in round bottom flasks or wide-neck filter bottles |
12/24 pieces |
12/24 pieces |
12/24/36 pieces |
12/24/36 pieces |
Dimensions of base unit |
width: 860 mm
height: 485 mm
depth: 650 mm |
width: 860 mm
height: 485 mm
depth: 650 mm |
width: 860 mm
height: 1050 mm
depth: 650 mm |
width: 860 mm
height: 1050 mm
depth: 650 mm |
Weight |
ca. 135 kg |
ca. 160 kg |
ca. 215 kg |
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Electrical connection (other voltages available) |
230 V, 50 – 60 Hz |
230 V, 50 – 60 Hz |
400 V, 50 – 60 Hz |
400 V, 50 – 60 Hz |
Max. power consumption |
ca. 2.1 kVA |
ca. 2.3 kVA |
ca. 1.8 kVA |
ca. 3.0 kVA |
Max. ambient temperature (unit is air-cooled, higher temperatures upon request) |
climate category SN+10°C to +25°C |
climate category SN+10°C to +25°C |
climate category SN+10°C to +25°C |
climate category SN+10°C to +25°C |
Model |
EPSILON 1-4 |
EPSILON 2-4 |
EPSILON 1-6D |
EPSILON 2-6D |
Ice condenser capacity |
max. 4 kg |
max. 4 kg |
max. 6 kg |
max. 6 kg |
Ice condenser performance |
max. 3 kg/24 h |
max. 3 kg/24 h |
max. 4 kg/24 h |
max. 4 kg/24 h |
Ice condenser temperature |
approx. -55°C |
approx. -85°C |
approx. -55°C |
approx. -85°C |
Shelf temperature control (T in °C) |
-40 (prefreezing) to +60 |
-70 (prefreezing) to +60 |
-40 (prefreezing) to +60 |
-50 (prefreezing) to +60 |
Shelves - quantity |
1 |
1 |
4+1 max. |
4+1 max. |
Shelf measurements (w x d, mm) |
270 x 400 |
270 x 400 |
225 x 300 |
225 x 300 |
Area (m2) |
0.11 |
0.11 |
0.07 - 0.28 |
0.07 - 0.28 |
Distance between shelves (mm) |
135 |
135 |
73mm (3+1) |
73mm (3+1) |
Sealing of vials in vacuum / N2 |
Optional |
Optional |
Optional |
Optional |
Flask drying |
Manifold with e.g. 4 controllable vacuum connections each (optional) |
Manifold with e.g. 8 controllable vacuum connections each (optional) |
Sterilization (H2O2) |
Optional |
Optional |
Optional |
Optional |
Refrigeration compressor
Number x KW |
1 x 0.6 |
2 x 0.6 |
1 x 0.6 + 1 x 0.5 |
1 x 0.5 + 2 x 0.6 |
Type |
air-cooled |
air-cooled |
air-cooled |
air-cooled |
Dimensions (w x d x h, mm) |
780x480x ca.520 |
780x480x ca.520 |
860x650x ca.1100 |
860x650x ca.1100 |
Electrical connection (V /Hz / kVA) |
230/50/3 |
230/50/3 |
3x400/50/3 |
3x400/50/3 |
Weight (kg) |
ca. 175 |
ca. 205 |
ca. 310 |
ca. 330 |
Interface |
LSC |
LSC |
LSC |
LSC |
Vacuum display |
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Vacuum control function |
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Temperature display: |
- Ice condenser (display) |
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- Shelves (display and control) |
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- product (measurement of 3 probes max.) |
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Lyo Control |
Optional |
Optional |
Optional |
Optional |
Determining end of drying: |
- Product temperature measurement |
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- Pressure-increase measurement |
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Optional |
Optional |
Weighing cell |
Optional |
Optional |
Optional |
Optional |
Manipulator for sample-retrieval during process |
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Optional |
Optional |
Programmer module |
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PC-Interface |
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PC-Documentations software Lyo LL-1 |
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Process-control system LPC-16 |
Optional |
Optional |
Optional |
Optional |
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