Applied_Biophysics_ECIS_Real_Time_Cell_Growth_Monitoring__Instrument_Comparison_Chart

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Applied Biophysics ECIS Real Time Cell Growth Monitoring

Instrument Comparison Chart

ECIS Instrument Selection Guide
	ECIS 1600	ECIS 1600R	ECIS 9600
	Applications	Applications	Applications

Maximum Number of Wells	16	16	96

AC Signal
Three fixed frequencies	X		X
Completely variable frequencies		X

Measurement
Impedance	X	X	X
Complex impedance (resistance and capacitance)		X
Superior sensitivity by locking to AC frequency (e.g. single cell detection)		X
Modeling Breakdown of data into cell parameters*		X

Applications

Cell proliferation assays	X	X	X

Cell attachment/spreading assays	X	X	X
Impedance changes during cell spreading	X	X	X
Measurement of electrode area coverage (capacitance)		X

Signal transduction assays	X	X	X
Impedance changes	X	X	X
Modeled changes in cell parameters		X

Wound-healing / migration assay	X	X	X
Fixed voltage and frequency parameter	X		X
Variable voltage as well as frequency parameters		X

Permeability of confluent cell monolayers	X	X	X
Changes in overall layer impedance	X	X	X
Modeling to provide true barrier function		X

Cell invasion assays	X	X	X
Based on impedance changes	X	X	X
Modeled changes in cell parameters		X

* Giaever and Keese, PNAS 1991

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